- Shay: "Connor may inherit the house, but you'll be Mentor."
- Liam: "We'll see."
- Shay: "Whatever you say, Prince Regent of the Assassins."
- Liam: "You call me that again and I'll throw you in the ocean!"
- —Liam O'Brien and Shay Cormac on the former's future.[来源]
In January 1752, he and Shay arrived at Port Mernier to rendezvous with Chevalier and his fellow smugglers. While the two were hunting, Chevalier's smugglers were captured. Arriving at his camp, Liam and Shay were both berated by Chevalier, to which the latter prompted a fisfight with Shay. At first, Liam did not intervene, but after seeing the situation, he broke up the fight and gave Shay a sword and a dagger and the two silently assassinated several Royal Navy sailors and freed the smugglers before claiming their sloop, the Morrigan. Shay became the captain of the ship and Liam his quater-master. With the Morrigan, the three Assassins sank the ships of the Royal Navy which attacked Chevalier's Man O' War, the Gerfaut. After this victory, the Assassins returned to the Davenport Homestead.
Two months later, at the Homestead, Liam and Shay witnessed the arrival of Adéwalé who wanted to take supplies for the population of Port-au-Prince after the earthquake that destroyed the city a year before, but also reported the dissapearance of two Pieces of Eden to Achilles, the Voynich manuscript and a precursor box, which together could give a map of Precursor Temples. During their meeting, Liam helped trained Shay in firearms with the use of his pistols. After Shay received from Achilles the mission to recover the two artifacts, he and Liam sailed to Port La Joye to meet up with Chevalier before sailing to Anticosti Island to meet up with the spy Le Chasseur who gave them a lead on the manuscript and the box, which is at the hands of the Master Templar Lawrence Washington.
In July, Liam and Shay met Achilles, Hope and Kesegowaase at Two Bends to inform them on Washington. Achilles tasked Shay and Liam to investigate on the Templar. With the Morrigan the Assassins followed a ship to Mount Vernon, Washington's mansion. Liam stayed on the Morrigan while Shay infiltrated the party organized by the Templar. After the Assassin killed the Master Templar, the Morrigan was attacked by the fleet near the mansion. Shay arrived on his ship and the crew escaped from their ennemies. While Shay doubted on the necessity to kill Washington, who was already dying from tuberculosis, Liam assured his friend that this was the right thing to do.
In April 1754, Liam and Shay met again with Chevalier and le Chasseur in the Anticosti's fortress to have information on Samuel Smith, the Templar who had the box. Aboard the Morrigan, the Assassins tracked Smth's ship, the Equitas, before she beached on Terra Nova. Shay followed and killed the Templar before reclaimed the box. Liam congratulated his friend for his actions but Shay doubt on the necessity of Smith's death. Liam reassured Shay that Smith was a menace, as their next target, James Wardrop.
Three months later, Liam and Shay met Hope at the Albany Congress. She informed them that Wardrop was there and that he had the manuscript. Shay tracked Wardrop while Liam and Hope team up to be sure the Templar didn't escaped. Shay succeded to kill Wardrop and took the manuscript for the Brotherhood. With the two artifacts and the help of Benjamin Franklin the Assassins located a Precursor Temple in Lisbon. Shay was sent to Lisbon but Liam couldn't followed his friend because of another assignment given by Achilles.
The two friends only met again at the begin of the year 1756, when Liam saw Shay accusing Achilles to voluntary sent him triggered an earthquake in Lisbon with the power of the Temple. Liam separated his friend and his Mentor. During the night Achilles called his Assassins to stop Shay who had steal the manuscript. Liam attempted to stop his friend by shooting on a powder keg which resulted to a small landslide but Shay escaped from the trap. The runaway Assassin was cornered to a cliff by his former allies. Liam pointed a gun to dissuade Shay to flee. Shay, who couldn't carry the deaths of the civilians of Lisbon, decided to kill himself by falling of the cliff to destroy the manuscript. Liam shouted to prevent the suicide of his friend but Chevalier shot on Shay who dived in the cold water with the manuscript.
At 1757, having known Shay's survival and now aiding the Templars, Liam and Kesegowaase attacked Albany in an attempt to reclaim the Voynich Manuscript that the Templar George Monro held after rescuing Shay. While Kesegowaase distracted Shay, which ultimately cost his life, Liam pursued Monro, killing or wounding his guards before setting the house on fire with the Colonel inside. With the manuscript recovered, the Assassins continued their search on the Precursor sites.
At 1759, the Assassins met once more to discuss the location of the Precursor site which Liam pointed out that Hope managed to replicate Franklin's experiment. The Templars, however, manipulated the British Army, and launched an attack on her mansion. Hope sent Liam away, who told her that they will depart. Soon after however, Liam went back to her mansion and found her dead, having been killed by his former friend Shay which may have an impact on his life and fueled his desire on avenging her and his fallen comrades by killing Shay should he be given the chance.
利亚姆很有耐心，沉稳老练，是个受人尊重的人。他曾毫不犹豫地制止了两名刺客之间的打斗。他的性格平和而冷静，但为了履行自己对兄弟会的使命，他可以毫不迟疑地放弃友谊。利亚姆对信条深信不疑，十分敬佩阿德瓦莱和其他殖民地刺客，从他们身上学习必要和有益的东西。Liam was, considered by Shay, also a "wise" man. Liam was not a man for small talk, being far more serious and driven than Shay, who was more laid back and prone to jokes.
Equipment and skills编辑
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Liam was a highly skilled Assassin, having been Achilles' first student and possessing over a decade's experience in the Order. A proficient marksman and swordsman, he was capable of defeating a number of British soldiers in quick succession. Accompanying this, Liam possessed a knowledge of sailing, acting as quartermaster of the Morrigan.
In terms of physicality, Liam was a skilled freerunner, capable of performing the Leap of Faith. His arsenal consisted of Hidden Blades, a sword and dual pistols, with the last of these appearing to be his preferred weapon. He was not only very confident, but also proud of his marksmanship; when Shay accused him of having been the one to shoot him in the back, Liam denied this, remarking that it was Louis-Joseph, and boasted that he never misses a shot to reinforce his claim.
- Liam is the Irish short form of William, which is derived from the elements wil "will, desire" and helm "helmet, protection". O'Brien is an Irish surname that means "descendant of Brian".
- In the memory "Scars", Liam is described as a "huge man with an axe", despite the fact that he is never seen with such a weapon throughout the game. However, his concept art does depict him with an axe.
- When playing events prior to Shay's defection from the Assassins, a glitch occurs where if the crew spots a prisoner-of-war ship, Christopher Gist can be heard reporting this news rather than Liam.
- A trailer of Rogue shows Shay killing Liam during their fight contrary to the events of the actual game where he dies after falling off a cliff with Shay. [来源请求]
- In the memory, "Non Nobis Domine", his body can neither be picked up nor looted by Shay after his death.