Earlier today, it was confirmed that Assasins creed:III will be set during the American revolution, a location placing third in the poll of where the game should take place on this wiki, and that was the overall most anticipated location. What makes this undeniable is that the informaton has been recieved from a lot off different sources, from the games offical facebook page, to shop workers snapping promotional art to game informer leaking a web banner.
Wether you like it or not, the tale of Desmond miles will end with an ancestor fighting for the freedom of America, as seen in released concept art.