In 1489, the Spanish Brotherhood of Assassins entered the city in search of a painting from a set created by Leonardo da Vinci that had been inadvertently gambled away by their associate, Jaime del Rada. The paintings were obtained by the Inquisition captain Diego de Burgos, who separated them and gave one to each of his underlings. Among those people was Alfonso Cavallero, a lieutenant who collected art. Finding Cavallero's villa, the Assassins stealthily broke in and recovered the painting.
Around 1511, the Templars commandeered the forges of the city's famous blacksmiths, causing them to flee to Madrid. The Assassins reclaimed their properties from the Templars, returning them to their rightful owners.
- Assassin's Creed: Revelations (mentioned only)
- Assassin's Creed IV: Black Flag (mentioned only)
- Assassin's Creed: Rebellion – The Art of the Heist (first appearance)