In legend, Seth was the brother of Osiris and Isis. He married Nephthys and fathered the mummification god of the dead, Anubis. Seth was also one of Ra's protectors who aided him in his battles against the Serpent of Chaos, Apep. Seth later killed and dismembered Osiris, resulting in Isis using the Ankh to resurrected him for one night, long enough to conceive his son and heir Horus.
- In art works, Seth is usually depicted as an enigmatic creature called the sha, a beast resembling no known creature, although it could be seen as a composite of an aardvark, a donkey, a jackal or a Fennec fox.
- One of the Isu messengers was called 'Seth Anath messenger'.