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The Basilica of Santa Maria del Santo Spirito, or simply the Santo Spirito, is a major church in the Oltrarno District of Florence.


The Italian architect Filippo Brunelleschi began designing the Santo Spirito in the year 1428. After his death, followers of his – Antonio Manetti, Giovanni da Gaiole, and Salvi d'Andrea – carried on his work. The sacristy was designed by Simone del Pollaiolo and the bell tower, built in 1503, was designed by Baccio d'Agnolo.


  • The Santo Spirito was only accessible after the Bonfire of the Vanities downloadable content was purchased.
    • Despite this, the Santo Spirito was not available in the Assassin's Creed II database, although it was mentioned in the Oltrarno District entry.
    • In addition the building was marked with dark grey on the Animus map, same as the landmarks featured in the database.


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