Botticelli used the notable Florentine beauty Cristina Vespucci as a model for his paintings and worked under the patronage of Lorenzo de' Medici, producing paintings such as The Birth of Venus, Pallas and the Centaur and Primavera. Like other rising artists of the time, he had his own workshop in Florence, and several assistants in his employ. Following the fall of the House of Medici, Botticelli became a supporter of the radical friar Girolamo Savonarola.
- Assassin's Creed II (mentioned only)
- Bonfire of the Vanities (mentioned only)
- Assassin's Creed: Renaissance
- Assassin's Creed: Project Legacy (mnemonic set only)