Romagna was largely dominated by marshes, wetlands, and a number of scattered buildings. It also housed the Forlì docks, where ships from other areas docked with the ports. People were often seen fishing from the wharves, or selling fish from market stalls nearby. During the Renaissance, the AssassinEzio Auditore da Firenze visited the location on several occasions.
The name Romagna came from the Latin word Romània, which was originally the generic name for "land inhabited by Romans", first appearing on Latin documents in the 5th century. It later took on the more detailed meaning of "territory subjected to Eastern Roman rule", whose citizens called themselves Romans (Romàioi in Greek), considering themselves the heirs of Imperial Rome. Thus the term Romània came to be used to refer to the territory administered by the Exarchate of Ravenna in contrary to other parts of Northern Italy under Lombard rule, named Langobardia or Lombardy. Romània later became Romandìola in Vulgar Latin, which meant "little Romània", which evolved into Romagna.
In 1480, Ezio Auditore rode into the area, after being chased through the Apennine Mountains by Borgia soldiers. He used the area to access a ferry up the coast of the Adriatic Sea to Venice alongside close friend Leonardo da Vinci, after initially being held up due to his lack of paperwork. Caterina Sforza, Countess of Forlì, solved this problem when she took a shine to Ezio, following his rescue of her from an isolated rock on the Forli docks.
In 1488, after recovering the Apple of Eden, Ezio Auditore and his uncle Mario decided to take the Apple to Forlì, where they met with Caterina in the wetlands outside the city. However, upon reaching the city, word spread that the forces of the Ludovico and Checco Orsi had invaded and gained control of the majority of the city.
After discovering that the gates to the city were locked, Caterina instructed Ezio to infiltrate the city via a secret entance, which involved Ezio swimming under the city drain and entering from there. While Caterina distracted the invaders with a volley of insults, Ezio dispatched any soldiers in his way and opened the gates to the city, allowing Caterina and her soldiers into the city where they retook it. After entering the city, Ezio and the others made their way to the citadel to fight off the attacking invaders, defeating them and reaching the inner citadel. However, upon reaching there, Caterina discovered her children were missing and that the Orsi brothers and their army of Borgia soldiers had begun breaching the citadel, forcing Ezio and the Assassins to defend. They were able to successfully fend off most of the attackers and hold the city. However, they were soon confronted by the Orsi brothers themselves.
They called out to Caterina, informing her that they had kidnapped her two children, [[BiancaRiario|Bianca]] and Ottaviano, explaining that they would only be returned once Caterina had handed over her father's map detailing the locations of the Codex pages. Caterina hurled insults at them in response, refusing to hand over the map. The Orsi brothers stated in return that she had one hour to hand over the map before they killed her children. Caterina turned to Ezio for help, asking him to rescue her children for her. Ezio agreed and handed over the Apple.
Ezio departed and headed for the Romagna countryside where he defeated the guards imprisoning Bianca, who then directed him to the location of her brother, Ottaviano. Ezio headed through the marshes to a nearby lighthouse, where he scaled the building, killed Ludovico and rescued Ottaviano. However, upon dispatching of Ludovico, Ezio learnt that the captured siblings had been a distraction, allowing for the theft of the Apple. Ezio hurried back to the city, discovering that Checco had acquired the Apple. Ezio tracked him down and killed the last Orsi brother and retrieved the Apple, though not before Checco managed to stab Ezio in the abdomen, causing him to lose consciousness and drop the Apple. As Ezio slipped into unconsciousness, he saw a black-robed monk with a missing finger pick up the Apple and walk away.
Ezio awoke afterwards inside the city, being tended to by Caterina after Forlì guards discovered him in the countryside whilst scouting the area. Upon regaining consciousness, Ezio explained to Caterina what had happened. She pointed him in the direction of a nearby abbey in the wetlands outside the city as a good spot to look for clues regarding the location of the black-robed monk. Additionally, Caterina gave Ezio the Codex map aswell. Ezio thanked her and left, heading for the abbey.
Ezio traveled through the Romagna marshlands until he reached the abbey, where he saved an Irish preist, Brother O'Callahan from Borgia thugs. Ezio questioned him about the monk with a missing finger, and Brother O'Callahan directed him to an abbey inside the city of Forlì.
Ezio returned to the city and headed for the abbey. However, once he arrived there, one of the priests recognized him as the murderer of Stefano da Bagnone, the Templar Ezio had assassinated nine years earlier. The priest attempted to run away, but Ezio caught up to him and tackled him. He quickly explained that Stefano's death was necessary, and managed to convince the priest of this. He then inquired about the identity of the black-robed monk with the missing finger, and the priest confirmed it to be Brother Savonarola. Ezio asked where he might have gone, and the monk said he may have returned to Florence.
Ezio left Romagna after this, heading for Florence to find Savonarola.
Romagna was the poorest region in Assassin's Creed II. Its surrounding area was flooded with dirty water and the buildings were ravaged and overgrown with weeds. Very few civilians wore affluent clothing (such as feather hats and scarfs), nor did they possess a respectable amount of money to pickpocket.
The Wetland Ebony and Wetland Ivory dyes for Ezio's robes were obtainable in Romagna from any Tailor, and granted the "Perfect Harmony" Achievement when worn together.