The Prince of Anhua rebellion was a rebellion by Zhu Zhifan, ruler of the princedom of Anhua and member of the Zhu imperial family, against the reign of the Zhengde Emperor in May 1510. Ambitious, the prince and his group of loyal supporters plotted against the hedonistic Emperor, using the resentment caused by the new taxes ordered by Liu Jin, an ally of the Templars and the true master of the Empire, to initiate an uprising.
On 12 May, the group of officials sent to collect the new taxes ordered by the imperial court were massacred by the conspirators during a banquet hosted by the prince, initiating the rebellion. Zhu then issued imperial edicts, requesting for reinforcements from the regional commanders, but loyal to Liu Jin, they ignored his commands. On 21 May, many of the rebels were killed following a battle against soldiers loyal to the throne, and the rebellion ended on 30 May, when one of Zhu's commanders betrayed him, killing his last supporters and capturing him in his own court.
Although his revolt was backed by the Assassins, who saw the opportunity to eradicate the rule of Liu Jin over the Empire, Zhu failed and one year after his capture was allowed to commit suicide. Ironically, the Assassins unintentionally succeeded in eliminating Liu Jin when his fellow Tiger, Zhang Yong, who had been sent to quell the rebellion, returned with false evidences implicating his master in the plot. Innocent of this crime, Liu was nevertheless executed and Zhang Yong, who was a Templar, became the new leader of the Tigers on behalf of his Order.