In 1499, the Ottomans gained a major victory over the Venetians at the Battle of Zonchio, destroying their naval forces. This allowed them to seize the Venetian territories of Lepanto, Modone and Corone.
At some point during the war, Pope Alexander VI, the Grand Master of the Italian Templars, tried to disrupt a temporary peace treaty between Venice and the Ottoman Empire, by sending some of his son's finest killers to Constantinople. As their boat left port in Rome, it was taken down by the Assassins with a volley of fire arrows, and the Assassins instead set sail for Constantinople.
In 1502, the Ottoman Assassin Yusuf Tazim and a contingent of Italian Assassins from Venice met in Greece to steer the conflict to a peaceful end, which was achieved in 1503, ushering in a brief period of peace on the Ottoman Empire's western border.
- Both Ezio Auditore da Firenze and Piri Reis noted that they lost many friends during the conflict.
- Assassin's Creed II (mentioned in Database entry only)
- Assassin's Creed: Project Legacy (mentioned only)
- Assassin's Creed: Revelations (mentioned only)