- "If you got nothing, go to New York. That way, if you leave with nothing, people don't ask why. And if you leave with something, then you are one lucky son of a bitch."
- ―A man's advice for Desmond Miles.[src]
The Assassin Connor came to New York with Benjamin Tallmadge in 1776, to investigate a plot to murder George Washington. Tallmadge learned the Templar and Continental soldier Thomas Hickey was involved: Connor tracked Hickey by following members of his counterfeiting racket. Unfortunately, Connor was arrested along with Hickey by soldiers who mistook him for a fellow counterfeiter, and was thrown into Bridewell Prison. The Templars framed Connor for the plot and planned to have him executed outside City Hall, with Washington attending. The Assassins - and Connor's father, Grand Master Haytham Kenway - stopped the hanging, and Connor assassinated Hickey for trying to kill Washington.
Afterwards, the east side of the city was greatly damaged due to the Great Fire, and New York passed from American control to the British. In the meantime, Connor recruited Deborah Carter, Jacob Zenger, and Jamie Colley to the Assassins after they helped him stop Templars taking advantage of these events. In 1778, Connor met with Haytham to find Benjamin Church, who had betrayed the Templar Order and the Continental Army, but discovered he had left New York for Martinique. Later, they worked together to find out British troop movements, learning the British planned to march on Monmouth.
In 1781, the disgraced American general Charles Lee was living in Fort George. Connor planned to infiltrate the fort while the French Navy bombarded the fort, so he could find and assassinate Lee during the chaos. However, Connor found that Haytham had sent Lee away, and the Templar, no longer willing to reconcile with his son, attempted to kill him. Connor assassinated his father. A year later, Connor found Lee presiding over Haytham's funeral. Lee escaped, but by eavesdropping on an accomplice on the HMS Jersey, learned he had left for Boston. A year later, after killing Lee, Connor watched the British depart on Evacuation Day, and met with Washington to discuss the country's future.
In 2003, after having fled from the Farm, Desmond ended up living in New York City, working as a bartender at a successful nightclub named Bad Weather. He would later revisit New York in 2012, specifically a Manhattan office, to recover a power source for the Grand Temple, though he came across opposition in the form of Daniel Cross.
- It was intended for Connor be present in New York during the Great Fire of 1776, but it was too difficult to program civilians to react to the burning part of the city, so the event was left out of Assassin's Creed III. The linearity of sequence 8 means the player avoids seeing the burned areas of the map until the game moves forward to 1777.
- Surpisingly enough, in modern-day New York, the Empire State Building, the Chrysler building or any of the iconic skyscrapers are nowhere to be seen.
- New York is depicted quite differently between Assassin's Creed III and Rogue. Entire buildings are different structurally or are made of different materials or are missing completely, stone walls are replaced with wooden palisades, different pavements are being used in the same place and a particular church is missing due to Rogue having its unique version of the city rather than reusing the ACIII version.