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Lysander served faithfully as the head priest at the Serapeum of Alexandria. However in around 48 BCE, the temple became involved in a controversy when the temple's Egyptian drummer was accused by his superior, the tanner Theon for stealing a lionskin. The drummer was subsequently jailed by the Phylakitai of the city in the Kibotos Arsenal. This led to many Alexandrian Egyptians avoiding the temple, resulting in the decrease of visitors.
When the Medjay Bayek of Siwa visited the temple to receive blessings for his journey, Lysander explained to him the reason for the temple's lack of visitors. Bayek agreed to help the priest rescue the drummer and prove his innocence. Bayek kept his promise to Lysander, as the drummer later returned to the temple, albeit with a broken leg. However, Theon the tanner also returned to the temple, confronting Lysander about the actions of the drummer. Bayek consequently retrieved the tanner's dyed lion skin from the bandits who had stolen it. Bayek was able to help Lysander negotiate with the tanner, ultimately clearing both the drummer's as well as the temple's name.
Shortly thereafter, Lysander enlisted Bayek's help again, this time to retrieve a cart of food stolen by the Ptolemies. Bayek did so, bringing the cart to him in the Egyptian district. However, this act caught the action of the Phylakitai, who put a bounty on Lysander's head, causing him to flee his temple and seek refuge in the Egyptian district. Bayek came across the priest in the district, and escorted him to the Iseion, a small temple on the island of Pharos. Bayek escorted Lysander on a boat through the canals beneath the city and eventually to the island, where he declared his name to Bayek while renouncing his priesthood.
- The name Lysander is Greek in origin, derived from the name Λυσανδρος (Lysandros) which means 'a release of a man'.