The flails used by Lucius Septimius, Julius Caesar's right-hand man, were weapons that appeared to be, at the very least, based off of Isu technology. He acquired them at some point between 48 and 44 BCE. When Aya infiltrated the Theatre of Pompey to assassinate Caesar on 15 March 44 BCE, Septimius stopped and fought her using the artifacts. Despite the weapons' powers of grabbing and lifting people into the air, and paralyzing them in levitation, he was unable to overcome his adversary.
Behind the scenes
Historically, use of the flail as a weapon didn't begin until the Late Middle Ages, making Septimius' use of such a weapon anachronistic.