During their early life, Bayek and Aya often traveled to the cave, where they eventually found love.
In around 48 BCE, Bayek returned to the site, where he reflected on his relationship with Aya, and pondered how it would be appropriate that the site of their beginning would also be where they would end. After their deaths, the cave served as their burial site, where they would remain until almost 2000 years later.
In October 2017, Layla Hassan ventured to Hotep Cavern to locate a relic of interest, but instead stumbled across the mummified remains of Bayek. Collecting his DNA, Layla set up her Animus to explore the genetic memories of Bayek. Through the Bleeding Effect, Layla later discovered Aya's sarcophagus, which had fallen down to a small hole. Layla collected the DNA from Aya's mummy before she climbed her way up and returned to her workplace.
Sometime after the sequencing Bayek's memories in the Faiyum Oasis, Layla was woken up by her colleague Deanna Geary, who alerted to her that Abstergo Industries had discovered her location and sent the Sigma Team to hunt both of them down for failing to comply with their orders. Layla was able to dispatch the attackers, but was unable to assist Deanna, who monitored the former from a hotel.
- Hotep Cavern is a "secret" location, easily missed by players aiming for the "Old Habits" achievement. Hotep Cavern is one of the few locations of interest in the desolate Qattara Depression, and does not appear on the map after synchronising. Discovery is based on clues written on a stone tablet in the modern-day cavern.
- Depending on the player's progress in the story, Layla will either have the stone translated, or be able to read it herself through the Bleeding Effect.
- The "relic of power" mentioned in the tablet is supposedly the random legendary item, not an Isu artifact, as is more common for "relics".
- If the player visits the site as Bayek, in the modern time Layla will mention that she "has been here before...as Bayek" when she goes outside.