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- "When I was flesh, I apprenticed with Hephaestus, the maker. The War of Unification raged. We created devastating Swords to end it, but then... killed. I created Shrouds, to heal."
- ―Consus, mentioning his master, Hephaestus[src]
Hephaistos was known as 'the maker' among the Isu, having created many Pieces of Eden, and at one point trained Consus, who later used his teachings to construct his own Pieces of Eden, such as the Shrouds, which helped counteract the use of the artifacts as weapons and introduce a method to heal injured Isu during the Human-Isu War.
Hephaistos was also responsible for the creation of what would later be known as the Spear of Leonidas - it could be improved at the Isu site known as the Ancient Forge on the island of Andros. The Forge held the apparent mould for the spear, as well as moulds for a sword, an axe and a halberd. Hephaistos also created a hammer held by the Cyclops Arges. 
Influence and legacy
Hephaistos' memory survived among humans as a revered god of smithing and fire, forgework and volcanoes, especially in Greco-Roman mythologies. In them, he was also called The Lame One, for he was believed to have a weak leg, either as a birth defect, or as a consequence of an accident.
Many of his creations survived the end of the Isu's reign, becoming objects of divine origin among humanity.
During the 5th century BCE the islands of Thasos and Lemnos were known as the Hephaistos Islands, with the latter housing a notable temple dedicated to Hephaistos. The volcanic island north of Argolis was called the Foundry of Hephaistos.
- In various stories in Greek mythology, when Hephaistos' limp was discovered by his mother, the goddess Hera, she threw him off Mount Olympus. Falling near the island of Lesbos, he was discovered by a number of sea deities.
- The mural depicting Hephaistos in Assassin's Creed: Odyssey is based on a vase painting from the 5th century BCE.
- Assassin's Creed: Syndicate (mentioned only)
- Assassin's Creed: Odyssey (statue only)
- The Fate of Atlantis: Fields of Elysium (mentioned only)