Giza is a desert region in central Egypt, located on the western bank of the river Nile. It is home to the Great Pyramids and the Great Sphinx, as well as several other monuments. In ancient times, it was the necropolis of the nearby city of Memphis, the capital of Egypt during the Old Kingdom.
During the 1st century BCE, Khaliset, a member of the Order of the Ancients, often travelled the region in search of rare minerals for her Order. In secret, Khaliset also sought the means to revive her deceased daughter, Eshe. However, she went rogue after discovering an Isu vault beneath the Great Pyramid.
In 48 BCE, the Medjay Bayek of Siwa travelled to Giza to track down and eliminate Khaliset. After being given info by Apollodorus' contact Mered, Bayek tracked Khaliset to the Great Pyramid and eliminate her.
In 46 BCE, after the death of most members of the Order of the Ancients and establishment of the Hidden Ones, Menkhtu, a follower of Medunamun, the Ibis of the Ancients, wore the mask of his former master and proclaimed himself "The Ibis Reborn", founding his own sect. They attempted to break into the Isu vault under the Great Pyramid, to touch the Vault pedestal to obtain the mysterious ancient power within to conquer Egypt. But his plan was eventually foiled by the Hidden Ones led by their Mentor Bayek.
- Assassin's Creed: Origins (first appearance)
- Assassin's Creed: Rebellion
- Assassin's Creed: Odyssey – Legacy of the First Blade: Bloodline (vision only)