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Francisco de Borja (1441 – 4 November 1511) was a Spanish cardinal and the seventh of ten cardinal-nephews of Pope Alexander VI.

In 1500, he sent an encoded letter to the head priests of the Followers of Romulus, saying that they had to command their followers to rid Rome of the Assassin Order. However, the letter was intercepted by Ezio Auditore da Firenze before it could be delivered.

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