Around 47 BCE, whilst playing outside of the Temple of Zeus, Esiocles witnessed the Medjay Bayek of Siwa, performing a Leap of Faith off of the temple's rooftop. Capturing Bayek's attention, Esiocles convinced the Medjay to entertain a group of the city's children by leaping off of various city landmarks' rooftops, including the city baths, the Temple of Apollo, and the Roman Akropolis. Upon completing the final jump, Esiocles bestowed upon Bayek the title "Flea of Cyrene".
Years later in 38 BCE, Bayek encountered an Esiocles living in a village south of the Valley of the Kings, in Upper Egypt, and was dismayed to learn that he was pursuing a career as a smuggler. Not wanting Esiocles to lead a life of crime, Bayek convinced him to abandon that path and to seek out a friend in Rome who would keep his "idle hands busy."
- The name Esiocles is Greek for "Glory of the Eagle" coming from αετός and κλέος.
- His name may also be an easter egg and allude to the famous Ezio Auditore da Firenze. Whether this was intentional is unknown.