In 1506, the Duke's wife, Lucrezia Borgia, discovered that the Assassin Ezio Auditore had broken into Belriguardo, evading the guards on high alert across the estate. Lucrezia was able to summon assistance, but Ezio escaped with one of her paintings, Leonardo da Vinci's Annunciation.
In 1598, the House of Este lost the Duchy of Ferrara. After their departure, the Delizia was leased to local farmers, who used its extensive structures as granaries and stables. Therefore, only portions of it have survived to this day.
- The banners within Belriguardo and the coat of arms worn by the guards were those of the Borgia, despite them not owning the estate and having long been disgraced.