- Ezio: "What about these poison bombs? How lethal are they?"
- Piri: "Quite lethal, dostum (my friend). We distill our poison from the datura plant. A pretty little flower with a deadly secret. This one kills... slowly but surely. Be very careful, for your sake and for others'."
- ―Piri Reis to Ezio, about datura bombs.[src]
Through the use of a casing filled with gunpowder and datura powder, the bomb would disperse toxic gas upon exploding, poisoning any nearby guards or civilians; as it was quite dangerous, care had to be taken so as to avoid endangering the latter.
Behind the scenes
Almogavar units were known to possess a weakness to datura bombs.
Coward Templar Den Captains are immune to Datura Powder bombs during their sprint to the den door.
An achievement named "Mosh Pit" could be unlocked by poisoning ten or more guards with one datura bomb.