Cosimo de' Medici (1389–1464) was an Italian statesman, ruler of the Florentine Republic during the Italian Renaissance, and head of the Medici family. He was a close friend of Ilario Auditore, who served as Gonfaloniere to Cosimo during his reign. Cosimo was also the grandfather of Lorenzo de' Medici and founded the Medici bank.
Worried about the rising influence of Cosimo de' Medici, the Albizzi, a rival Florintine banking family, had him imprisoned in the Palazzo della Signoria. By gaining influence behind the scenes, Cosimo rose to power in 1434 whereupon he exiled the entire Albizzi family except for Luca, who had been loyal to him.
- Assassin's Creed II (mentioned in Database entry only)
- Assassin's Creed: Project Legacy (mnemonic set only)
- Assassin's Creed: Identity (mentioned in Database entry only)