Charles inherited the Faith prong of the Trident of Eden and passed it on to Hernán Cortés, who used it in his conquest of the Aztec Empire. He also played a vital part in the Italian Wars, and his forces sacked Rome in 1527, capturing Pope Clement VII.
- Assassin's Creed: Project Legacy (mentioned only)
- Assassin's Creed: Brotherhood (mentioned in Database entry only)
- Assassin's Creed: Last Descendants