By the middle of the 13th century, both the Assassin Brotherhood and Knights Templar held presence in the city. In 1340, both the Assassins and Templars were looking for a Piece of Eden known as the Scepter of Aset. The Assassin Numa Al'Khamsin was heavily involved in the conflict in the city.
In late 2012, William Miles, the leader of the Assassins, traveled to Cairo to obtain a power source for the Grand Temple from the Egyptian Museum and arrived there on 9 December. Two days later, William was captured by the Templars' Sigma Team led by Juhani Otso Berg, and brought to Abstergo Industries' facility in Rome.
- Assassin's Creed III (mentioned only)
- Assassin's Creed 4: Hawk
- Assassin's Creed: Unity – Dead Kings (mentioned only)