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5th century BCE
During the 5th century BCE the worship of Asclepius was widespread in the Greek world, and shrines and temples for him could be found here and there. Among the most notable was the Sanctuary of Asklepios in Argolis.
However, even Argolis' sanctuary was overshadowed by the island of Kos, where the followers and the very descendants of Asklepios, the Asklepiads lived. One of the regions of the island was named after them as the Highlands of Asklepiades, and Astypalia City housed the Hippokratic School of Medicine.
1st century BCE
- Aesclepiadae is a term used to refer to a group of people following Asclepius; in mythology, 'Aesclepiadae' includes all the sons and daughters of Asclepius. Among humans, the term was used of physicians, banding them together as a "clan of Aesclepiadae".
- Praxilla, a healer of Balagrae, had a ring with the rod of Asclepius emblazoned on it.
- Rod of Asklepios has become the emblem of the medical field. It is, however, often confused with the caduceus.
- According to some versions of the stories, Asklepios was a member of the Argonauts.