- Herodotos: "Argolis! The land of science and home to the legendary city of Argos."
- Kassandra: "I never thought I would get to see it with my own eyes."
- Herodotos: "The tomb of King Agamemnon, the sanctuary of Asklepios, the old Minoan ruins! The history here is astounding."
- —Herodotos and Kassandra discussing Argolis[src]
Argolis, also called the Argolid and known as the Birthplace of Medicine, is a regional unit of Greece situated in the easternmost part of the Peloponnese. Its history is extensive even for that of Greek regions, with the region's capital city Argos once serving as one of the most dominant powers of Greece during the Mycenaean period.
In the 5th century BCE, the fairly populated region relied on the bronze statues of Polykleitos and the Sanctuary of Asklepios near Epidaurus for income. The latter was a popular site for travelers to visit, often in search of the famed physician Hippokrates, and it also played a substantial role in the development of Hippocratic Oath. Because of its abundance of flowers and herbs, the land was a vital source for many medicines in ancient Greece.
The region of Argolis was made up of twelve regions and the island volcano Foundry of Hephaistos:
- Ancient Ruins of Perseus
- Battlegrounds of Argos
- Hera's Watch
- Kingdom of Hope
- Mount Koryphe
- Mount Koryphum
- Palace of Agamemnon
- Promontory of Skylla
- Sinkholes of Herakles
- Valley of Dreams
- Wetlands of the Hydra
- The emblem of Argos features the head of a dog, possibly referencing Argos, the faithful hound of Odysseus in Homer's Odyssey.
- While in-game the emblem shows the dog with its mouth open, teeth bared, the emblem printed in The Art of Assassin's Creed: Odyssey and found in the message boards of Argolis shows the dog with its mouth shut.
- According to Greek mythology, the region was the home of Argus Panoptes, an 'all-seeing' Giant set by Hera to guard the nymph Io against Zeus' advances.