During the Peloponnesian War, many of the island nations throughout the Aegean Sea sided with either Sparta's Peloponnesian League, or Athens' Delian League. Because of this the navies of various nations regularly patrolled the sea. The Eagle Bearer 's ship, the Adrestia , frequently plied the waters of the Aegean at this time. The Cult of Kosmos ' Gods of the Aegean Branch controlled the Aegean's trade routes, until the branch collapsed after the intervention of the Eagle Bearer.
Roman Civil War
In 48 BCE, Cleopatra of Egypt, dispatched Aya and Phoxidas to the Aegean in search of the Roman general Pompey, who she sought to secure alliance with in order to capture the throne from her brother Ptolemy XIII. Aya and Phoxidas destroyed a number of Ptolemy's triremes before meeting with Pompey's fleet, which then also came under attack from Ptolemy's fleet.