User blog comment:Master Sima Yi/Assassinews 10-05'12 — World Gameplay Premiere/@comment-184.146.158.206-20120521221451/@comment-1153722-20120521222334

AC3 will wrap up Desmond's story. And the answer to that question is the same as how Connor relates back to Altaïr and Ezio; nobody knows. Plus Clay also had Chinese and Japanese ancestry (as can be concluded from the cryptic messages he wrote in the Abstergo laboratory), don't see why Desmond or any other American wouldn't.