User blog comment:Vatsa1708/New AC reveal in May, Brotherhood PC release date confirmed./@comment-2118482-20110224162555

I think it would make sense for ACIII to be set in Civil War America, for in one of the glyphs in ACII, Subject 16 (Who is related to Desmond) says the following: "I'm holding a rifle. Gettysburg is in the distance." And Miles and 16 have the same ancestors.