Confrontation in the Vatican

At the end of Ezio's epic journey, the confrontation in Rome is the Assassin's jouney to the Sistine Chapel to assassinate the leader of the Italian Templars, Rodrigo Borgia, currently known as Pope Alexander VI. Ezio went out on this mission to stop the reign of the Templars over Italy and to secure a known Piece of Eden, the Papal Staff. As the Prophet, Ezio needed the staff in conjuntion with the Apple of Eden to fufill the phophecies of his coming.