User blog comment:Master Sima Yi/Assassin's Creed: Project Legacy announced/@comment-2152155-20101001202514/@comment-1153722-20101001202911

It most likely is. Nothing hints to it being non-canonical. Chapter 1 is about Bartolomeo during the Battle of Agnadello and the questions Abstergo asks you after it hint to Bartolomeo's motives actually being a Piece of Eden, just like in the AC II's database entry.

Why would it be non-canonical anyways?