User blog comment:Master Sima Yi/New settings poll!/@comment-3524429-20120317144959

I think modern times is next anyway. Sure, Ubisoft SAID ACIII was the end of Desmond's story, but that may change. Someone on YouTube discovered an interesting pattern: every three centuries or so, a new assassin emerges.

1100s - Altaïr 1400s - Ezio 1700s - Connor 2000s - Desmond

So, I think there will be at least one more game, with desmond as the main assassin.