Manuel

Manuel may refer to:
 * Manuel I of Portugal, the 14th King of Portugal who allied himself with the Templars in Assassin's Creed: Brotherhood
 * Manuel Palaiologos, heir to the Byzantine Empire throne and a character in the upcoming game ''Assassin's Creed: Revelations
 * Manuel Tadros, a Canadian voice actor who provides the voice for Rodrigo Borgia in Assassin's Creed: Lineage, Assassin's Creed II, and Assassin's Creed: Brotherhood