La Belladonna

La Belladonna was one of the first French ships that carried aid to the Continental Army, even starting before France officially joined the Revolution. Before it left France, the ship was repainted to keep its destination secret.

It's cargo was deemed important enough for La Belladonna to be escorted by the USS Randolph, the Continental flagship captained by Nicholas Biddle. The Randolph, however, left La Belladonna after two weeks, leaving it without protection.

The Aquila, captained by the Assassins Connor and Robert Faulkner then came to escort La Belladonna, which was attacked by a large fleet of British ships. La Belladonna destroyed ten ships, after which its mainmast was destroyed and the Aquila destroyed the remaining ships of the fleet.

Reference

 * Assassin's Creed III