User blog comment:Campbell430/New Assassin's Creed for 2011/@comment-69.11.149.104-20101129235354/@comment-69.230.78.29-20101202031440

Wait, I thought Ezio was the closest blood ancestor between Desmond and Subject 16, so I doubt Desmond truly knows who 16 was based on the DNA memories. The closest DNA memories between them would be from Ezio. That doesn't mean Desmond could already know (or at least guess) who 16 was due to his childhood background or have gained suspicions through the use of the animus.