Cleopatra

Cleopatra VII Philopator (January 69 BC – 12 August 30 BC) was the last effective Pharaoh of the Ptolemaic dynasty of Egypt. At first, she shared power with her father and later, her brothers, whom she married. She eventually gained sole control through plotting and murder. Cleopatra then started a liaison with Gaius Julius Caesar, who she had a child with: Caesarion.

After Caesar's death, she aligned herself with Marcus Antonius, who she also had children with. Antonius eventually committed suicide after losing the Battle of Actium.

Soon after, Cleopatra was assassinated by Amunet, who used a poisonous snake (presumably an asp) to kill the ruler. It is possible that Cleopatra was in possession of a Piece of Eden, which would account for her assassination. Considering that Alexander the Great is said to have been in possession of the Sword, and that his sarcophagus is believed to have been transferred first to Memphis and then to Alexandria following his death, it it quite possible Cleopatra came into possession of it, perhaps also using it to influence Julius Caesar's interest in her, and his so-called Alexandrian War.

Trivia

 * In reality, Cleopatra committed suicide with a poisonous asp after the Battle of Actium.