User blog comment:Subject 16*/Assassin's Creed: Revelations - News/@comment-76.99.188.106-20110507205934/@comment-3276576-20110508125756

The whole memory- and Animus-system wouldn't work anymore, if Desmond died he would actually be dead, so no. The only way to give Desmond proper missions (and not just exploring places like in ACB) is to relive his past memories - and that's what they are going to do in ACR.