Spanish Brotherhood of Assassins

The Barcelona Assassins Guild was a Spanish guild, which was closely tied with the Spanish royal family.

Renaissance
In 1491, Tomás de Torquemada was fooled by Rodrigo Borgia, the Grand Master of the Templar Order, into believing that the Assassins were heretics. As a result, the Spanish Inquisitors arrested and burned members of the Assassins Guild. Luis de Santángel, an Assassin and companion of Christoffa Corombo, informed the Italian Assassin Ezio Auditore da Firenze of the Inquisition, which caused Ezio to sail for Spain. The leader of the Assassins Guild, Raphael Sanchez, met with Ezio, who assigned him to kill several high-ranking Inquisitors.

However, the Inquisition killed most of the Assassins. By 1498, both Sanchez and Santángel had died, and with their deaths the Assassins had no grip on the Spanish royal family and the guild was deserted.