Ottoman–Venetian War

The Second Ottoman–Venetian War was fought between the Ottoman Empire and the Republic of Venice, lasting from 1499 to 1503.

At some point during the war, Pope Alexander VI, the Grand Master of the Italian Templars, tried to disrupt a peace treaty between Venice and the Ottoman Empire, by sending some of his son Cesare Borgia's finest killers to Constantinople. As their boat left port in Rome, it was taken down by the Assassins with a volley of fire arrows, and the Assassins instead set sail for Constantinople. In 1502, the Ottoman Assassin Yusuf Tazim and a contingent of Venetian Assassins met in Greece to steer the conflict to a peaceful end, which was achieved in 1503, ushering in a brief time of peace on the Ottoman Empire's western border.

Trivia

 * Both Ezio Auditore da Firenze and Piri Reis noted that they lost many friends during the conflict.