User blog comment:JAlbor/Wikia at E3 2012/@comment-6517-20120523015213/@comment-1153722-20120523054933

I may be able to ask one of the devs this. But the Brotherhood novel would imply it's not long after 1506, since Pope Julius II is the one who proposed to Ezio to place the hint for the password.

And anon, your sarcasm is pointless.