User blog comment:D. Cello/Assassinews 10/11 -- Desmond's Ancestry Revealed/@comment-174.252.80.25-20111107012508

Obviously Ezio is a descendant of those whocame before. And Sofia Sorto is a direct descendant of Altair and she doesnt know it. Thus, at the end of Rev they get married and Desmond in turn is the descendant of Altair and Ezio who have no blood relation with each other.