User blog comment:KillHil/Assassin’s Creed III Ventures into the Wild/@comment-5123212-20120412030414/@comment-4636255-20120412055404

Sure you should play it, or you'll be confused as hell about what's going on. I played ACII before ACI, and had know idea what the animus is, and thought that Desmond was both Subject 16 and 17. :/