User blog comment:Master Sima Yi/Assassinews 04-06-'12 — E3 hub/@comment-78.146.201.52-20120606001750/@comment-1888015-20120606005522

I believe it has been stated in the Game Informer article for AC3:Liberations that Aveline is not Desmond's ancestor. As such, she can't be related to him, as she would have had to concieve a child that would have led into Desmond's direct bloodline.