User blog comment:JAK-90/Assassin's Creed III ideas/@comment-74.75.85.245-20101205060308/@comment-1153722-20101205222025

They are already discussing what time period they are going to do next, so yes, the Animus will be used again. They also said that with each numeral title they will have a new ancestor.

And put the goddamn spoiler tag up there. I guess it's too hard.