User blog comment:Master Sima Yi/Assassinews 12-11-'11 — Assassin's Creed: Brotherhood launch trailer/@comment-5336493-20101112130044/@comment-1365906-20101115023916

Both he and Cesare caught that fever after dining with a cardinal, Adriano da Corneto. Cesare was younger and survived. The pope, well, let's just say that it was a horrible way to go. Quoting wikipedia entry:

"Alexander VI's stomach became swollen and turned to liquid, while his face became wine-colored and his skin began to peel off. Finally his stomach and bowels bled profusely. After more than a week of intestinal bleeding and convulsive fevers, and after accepting last rites and making a confession, the despairing Alexander VI died on 18 August 1503 at the age of 72. He is believed to have uttered the last words, "I'll come, I'll come. It's normal for you to call me. But wait a bit more," before his death."