User blog comment:Jasca Ducato/*Spoilers* Juno, Eagle Vision and all that. *Spoilers*/@comment-3230258-20101124184805

"Now, who exactly she is referring to I do not know, although I suspect she may be talking about Ezio and his descendant, Desmond, though I cannot be sure."

I believe Juno's referencing time here as if it were a living thing; metaphorically.

"I don't see a section here explaining why TWCB had Desmond stab Lucy."

I believe, via Juno's comment of "The Path must be opened. You cannot escape your part in this," that Lucy was standing in the way of Desmond's romantic destiny with this woman who's supposed to "accompany [him] through the gate." By killing Lucy - if she is, indeed, dead - Desmond's 'Path' is opened up to eventually bare a child with the mystery woman and have the son that Subject 16 alludes to in Brotherhoods 'The Truth' program.